The effect of lipocortin 1 on neutrophil deformability
Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Foot Rest Lc1 to the inflamed site is ineffective.We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in